NV1 Breakthrough Technology Targeting Tendon Healing
Understanding how this
protein works in the body
Neural EGFL like 1 as a potential pro-chondrogenic, anti-in ammatory dual- functional disease-modifying osteoarthritis drugArthritis and joint deterioration in animals is an inflammatory condition that causes pain and destruction in joints, affecting millions of animals in the US alone. In this study it shows for the first time the emerging role of neural EGFL like NELL1.
Neural EGF-like protein 1 (NELL-1): Signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine
Nell-1 showing the promise of a emerging drug application for bone formation. Synergistically working with Bone Morphogenic Protein (BMP) -2 and -9.
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
Nell1 signals the protein kinase C-beta1 (PKC-beta1) binding protein. Belonging to the new class of signaling cell molecules that control differentiation and cell growth.Continue reading
Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3-Mediated Indian Hedgehog Signaling
Nell-1 as a Runx2 to be a growth factor for forming cartilage, then separating and maturing.
Anti-inflammatory Properties Of Nell-1 On Human Articular Chondrocytes In Vitro.
Nell-1 showing the potential to reduce the progression of cartilage disease.
Nell-1 Is a Key Functional Modulator in Osteochondrogenesis and BeyondNell-1 showing the reduction of blood vessels needed for tumor growth, and anti-inflammatory characteristics over BMP-2.
NELL-1 induces Sca-1+ mesenchymal progenitor cell expansion in models of bone maintenance and repair
Using local implantation or intravenous delivery NELL-1 showed induced bone formation with large and small animal models.
Controlled release of NELL-1 protein from chitosan/ hydroxyapatite-modified TCP particlesNELL-1 maintaining a slow, and steady release for up to 28 days using Chi/HA-TCP.
NELL-1 Promotes Cartilage Regeneration in an In Vivo Rabbit Mode
This study shows NELL-1 possibly has the ability to produce functional cartilage with properties close to the original cartilage.