Science Innovation Passion
Current research using NV1, an extracellular signaling protein expressed in embryological and early neonatal development. Injecting into the damaged tendon may provide a broadly effective process to directly regulate the development, structure, function, repair, and regeneration of tendons.
NV1 reduced the concentrations of key pro-inflammatory molecules (e.g., IL1-β, 1L8)
Induced migration of endothelial cells, therefore, inducing vascularization of the region
Known gene and signaling proteins in NV1: tenascin C, collagen V, Bmp7, Osteoblast Specific Factor 2, Lubricin
Migration of mesenchymal stem cells by two- to three-fold, speeding the healing of the tissue